HEALTH-SPAN project, based on the collaboration of Apphia Laboratories and Qualia Pharma with one of the most recognized research centers in Greece, National Hellenic Research Foundation (NHRF), suggests the development of new dietary supplements, enriched with extracts and active components derived from Greek Flora. The new product line will incorporate innovative health claims, based on great scientific achievements within the field of Biomedical Sciences, for whom is expected to elucidate underlying mechanisms of processes relevant with human aging, These include telomeres’ and telomerase discovery (Nobel Prize 2009), the discovery of the proteasome, a complex responsible for protein degradation, with a pivotal role in many of the hallmarks of aging and a promising target for therapeutic interventions and also the epigenetics, a field that studies non heritable alterations in genes’ expression. In this direction, a variety of extracts/substances derived from the Greek and Mediterranean Flora, will be tested by the NHRF, in order to assess their ability to promote well-being. The anti-aging activity of the selected extracts/ substances and their potential combinations will be initially evaluated in vitro in human cell cultures. The results of in vitro evaluation will define the formulation of the new product, which will be further tested in vivo in healthy volunteers. The clinical trial is expected to provide the new product with credible scientific evidence in order not only to validate existing health claims about the active components, but also to create new.