Feel Healthier, Perform Better, Live Longer

As the body ages, its cells and communication systems become less balanced and efficient, which leads to greater production of free radicals and increased signaling of inflammatory cytokines and, thus, deterioration of cells and tissues.

KHELMA LONGEVITY MEDITERRANEAN FORMULA is the only supplement clinically proven to:

Support long term healthy cellular function
Support telomere integrity
Increase proteasome levels
Decrease levels of oxidized proteins
Support healthy epigenetic profile
Activate genes of youth

KHELMA LONGEVITY MEDITERRANEAN FORMULA Ingredients

K-Age™ (Resveratrol & Olive synergistic complex)

K-age™ is an innovative proprietary synergistic complex obtained from Polygonum cuspidatum root and Olea europea (Olive) fruit extracts which provides biologically enhanced trans-Resveratrol. Resveratrol works inside every cell in the body to help rejuvenate the mitochondria, the powerhouses that keep cells functioning properly. Resveratrol contained in the K-age™, favorably enhances the activation of cellular sirtuin proteins (longevity factors). Olive Polyphenols prevent and repair cellular damage caused by free radicals, prevent oxidation of low density lipoproteins, reduce the risk of coronary heart disease, improve glucose metabolism and skin health. More recently, studies have revealed that olive polyphenols are related also other important activities including anti-amyloidogenic activity, cell signaling modulation, effects on telomere length and modulation of the sirtuin proteins. K-age™ aims to prevent and repair cellular damage caused by free radicals, supports telomere integrity, supports healthy epigenetic profile and prevents the accumulation of damaged components in the cell by increasing proteasome levels and decreasing the levels of oxidized proteins.

Olea europea (Olive)

Olive leaf extract comes from the leaves of olive plants, and is distinct from olive oil; the leaf extract contains phenolics such as oleuropein, and appears to have highly protective effects against LDL oxidation and may also benefit glucose metabolism and skin health. Olive phenolics in general, which are present in high levels in olive leaf extract, appear to potently protect LDL cholesterol from oxidation. This is attributed to the anti-inflammatory effects of hydroxytyrosol, and appears to be active at a low enough dose to apply to consumption of olive product consumption. Olive leaf may also influence levels of lipoproteins in a beneficial manner (LDL, HDL, total cholesterol, although the actual changes in lipoprotein content is rather small. Overall, olive phenolics are more anti-artherosclerotic than they are cholesterol reducing.

Punica Granatum (Pomegranate)

Pomegranates can help prevent or treat various disease risk factors including high blood pressure, high cholesterol, oxidative stress, hyperglycemia, and inflammatory activities. It is demonstrated that certain components of pomegranate such as polyphenols have potential antioxidant, anti-inflammatory, and anticarcinogenic effects. The antioxidant potential of pomegranate is more than that of red wine and green tea, which is induced through ellagitannins and hydrosable tannins. Pomegranate can reduce macrophage oxidative stress, free radicals, and lipid peroxidation. Moreover, pomegranate fruit extract prevents cell growth and induces apoptosis, which can lead to its anticarcinogenic effects. In addition, promoter inhibition of some inflammatory markers and their production are blocked via ellagitannins.

Vitis vinifera (Grape)

The dietary consumption of grape and its products is associated with a lower incidence of degenerative diseases such as cardiovascular disease and certain types of cancers. Most recent interest has focused on the bioactive phenolic compounds in grape. Anthocyanins, flavanols, flavonols and resveratrol are the most important grape polyphenols because they possess many biological activities, such as antioxidant, cardioprotective, anticancer, anti-inflammation, antiaging and antimicrobial properties.

Vitamin B3 (Niacin)

Clinical research demonstrates that Niacin, is a highly efficient precursor to NAD+. Incorporating Niacin into the body has been shown to restore NAD+ levels in laboratory models, combating age-related decline in the NAD+ supply that cells experience. Preclinical studies link the restoration of NAD+ supplies to an improvement in metabolic efficiency and overall health. NAD+ is essential for energy production and DNA repair. The most important NAD+ benefit is promoting rapid DNA repair and fueling beneficial longevity proteins. Failure to repair damaged DNA can result in cell death or transformation into malignant or senescent states. NAD+ levels markedly decline with age. NAD+ deficit manifests clinically in the form of degenerative disorders of the brain, heart, and other tissues. In animal studies, regenerative effects have been observed in the brain when NAD+ is restored. Sleep quality deteriorates with normal aging in many people. Restoring youthful NAD+ levels in the brain may support a healthy circadian rhythm. Loss of NAD+ activity is linked to type II diabetes. In mice, administration of an NAD+ precursor restores insulin sensitivity and protects against the diabetic impact of a high-fat diet.

KHELMA LONGEVITY MEDITERRANEAN FORMULA Benefits

KHELMA LONGEVITY MEDITERRANEAN FORMULA is a Food Supplement formulated to support well-being at the cellular level

Prevent and repair Cellular Senescence
Protects cells from Oxidative Stress
Prevents visible signs of aging
Provides brain boosting benefits
Improves cardiovascular function
Enriched Feeling of vitality and well-being

Recommended for Adults

It is suitable for long-term use in adults of all age groups.

One Capsule Per Day

It is recommended a daily intake of one capsule in the morning, with or without food. Each bottle contains a 30-day supply.

No Animal Products

Vegetarian, vegan, gluten-free, nut-free, and contains no artificial colors or flavors.

EU and EFSA recommendations

The products are manufactured under Good Manufacturing Practice (GMP) protocols and meet current EU legislation and EFSA regulation and guidance.

Apphia Laboratories S.r.l.

Via Casilina Sud 69/E, 03013 Ferentino (FR), Italy

Email: apphia@apphialabs.com

Tel: +39 0775 1831004