As we age, metabolic processes do not operate as well as when we were younger. EF ZIN is a daily supplement developed by Apphia Laboratories clinically proven to:
EF ZIN contains Olvit an innovative proprietary synergistic complex obtained from Olea europea (Olive) and Vitis vinifera (Grape) which provides biologically enhanced olive and grape polyphenols, key ingredients of the Mediterranean diet. Polyphenols prevent and repair cellular damage caused by free radicals, prevents oxidation of low density lipoproteins, reduce the risk of coronary heart disease, improve glucose metabolism and skin health. More recently, studies have revealed that polyphenols are related also other important activities including anti-amyloidogenic activity, cell signaling modulation, effects on telomere length and modulation of the sirtuin proteins. There are polyphenols that are able to cross the blood—brain barrier with multiple effects on pathways involved in neurodegeneration and ageing may be proven efficacious in the treatment of age-related diseases such as Alzheimer’s disease.
EF ZIN contains Resveratrol from Polygonum cuspidatum root, a powerful polyphenol found also in several types of plants, including red grapes, blueberries, and nuts. Resveratrol works inside every cell in the body to help rejuvenate the mitochondria, the powerhouses that keep cells functioning properly. Several lab studies have shown that it may improve metabolic health, in particular by activating sirtuins. The Resveratrol contained in the EF ZIN, favorably enhances the activation of cellular sirtuin proteins (longevity factors). NAD+ is required for our sirtuins to function. As we age, NAD+ levels plummet, which impedes the ability of resveratrol to deliver its benefits. When sirtuins are activated, the end result is delayed ageing, which has been demonstrated in a wide spectrum of experimental models, including mammals. Sirtuins that are activated by resveratrol require NAD+ as their energy substrate. Loss of NAD+ impedes beneficial sirtuin function. Younger people have high NAD+ levels that enable them to benefit from the sirtuin-boosting effects of resveratrol. To improve the functionality of sirtuin proteins, it makes sense for maturing individuals to boost their NAD+ levels. The good news is that a precursor to NAD+ can be found in Vitamin B3. The dosage recommendation of EF ZIN can enable older people to restore cellular NAD+ to more youthful profiles.
Camellis sinensis has been implicated in benefiting almost every organ system in the body. It is cardioprotective, neuroprotective, anti-obesity, anti-carcinogenic, anti-diabetic, anti-artherogenic, liver protective and beneficial for blood vessel health. Camellia sinensis contains also Epigallocatechin-gallate (EGCG) that regulates multiple pathways that influnce aging in a broad range of tissues. EGCG uniquely regulates the Wnt pathway, which is vital in determining developing cells’ proper fate and preventing cancer. EGCG also prevents sugar-induced damage to tissues throughout the body, helping to suppress their pro-aging effects. Scientists found that these compounds reduced cellular aging and various processes that contributed to aging by beneficially modulating a group of signaling pathways that led to the formation of senescent cells. Most of these pathways are known to contribute to, or protect against, development of senescent cells, and all have been shown to protect against aging at the cellular level.
EF ZIN contains Vitamin B3 (Niacin). Clinical research demonstrates that Niacin, is a highly efficient precursor to NAD+. Incorporating Niacin into the body has been shown to restore NAD+ levels in laboratory models, combating age-related decline in the NAD+ supply that cells experience. Preclinical studies link the restoration of NAD+ supplies to an improvement in metabolic efficiency and overall health. NAD+ is essential for energy production and DNA repair. The most important NAD+ benefit is promoting rapid DNA repair and fueling beneficial longevity proteins. Failure to repair damaged DNA can result in cell death or transformation into malignant or senescent states. NAD+ levels markedly decline with age. NAD+ deficit manifests clinically in the form of degenerative disorders of the brain, heart, and other tissues. In animal studies, regenerative effects have been observed in the brain when NAD+ is restored. Sleep quality deteriorates with normal aging in many people. Restoring youthful NAD+ levels in the brain may support a healthy circadian rhythm. Loss of NAD+ activity is linked to type II diabetes. In mice, administration of an NAD+ precursor restores insulin sensitivity and protects against the diabetic impact of a high-fat diet.
Cellural Metabolism
Resveratrol
Camellia sinensis
Sirtuins Boosting effect
Increases intracellular
NAD+ levels
Sirtuins Boosting effect
Preventing Senescence
DNA Repair
Sirtuins
Olvit
Polyphenols
Mitochondrial Function
Energy Production
NAD+
Vitamin B3 (Nicotinamide)
NAD+ Precursor
EF ZIN by boosting intracellular NAD+ levels and activating sirtuins helps to promote cellular metabolism, mitochondrial function and energy production
EF ZIN is a Food Supplement scientifically formulated to support Metabolic Function and Well-Being
Apphia Laboratories S.r.l.
Via Casilina Sud 69/E, 03013 Ferentino (FR), Italy
Email: apphia@apphialabs.com
Tel: +39 0775 1831004
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