Metabolic Youth Activator

As we age, metabolic processes do not operate as well as when we were younger. EF ZIN  is a daily supplement developed by Apphia Laboratories clinically proven to:

  • Support metabolic health and optimization
  • Promote a healthy cellular aging process
  • Increase and sustain NAD+ levels
  • Activate sirtuins, which play a key role in cellular health
  • Support cellular energy and helps maintain healthy DNA
  • Maintain hundreds of integral processes in your cells

EF ZIN Ingredients

Olvit™ (Olive & Grape synergistic complex)

EF ZIN contains Olvit an innovative proprietary synergistic complex obtained from Olea europea (Olive) and Vitis vinifera (Grape) which provides biologically enhanced olive and grape polyphenols, key ingredients of the Mediterranean diet. Polyphenols prevent and repair cellular damage caused by free radicals, prevents oxidation of low density lipoproteins, reduce the risk of coronary heart disease, improve glucose metabolism and skin health. More recently, studies have revealed that polyphenols  are related also other important  activities including anti-amyloidogenic activity, cell signaling modulation, effects on telomere length and modulation of the sirtuin proteins. There are polyphenols that are able to cross the blood—brain barrier with multiple effects on pathways involved in neurodegeneration and ageing may be proven efficacious in the treatment of age-related diseases such as Alzheimer’s disease.

Resveratrol from Polygonum cuspidatum root

EF ZIN contains Resveratrol from Polygonum cuspidatum root,  a powerful polyphenol found also in several types of plants, including red grapes, blueberries, and nuts. Resveratrol works inside every cell in the body to help rejuvenate the mitochondria, the powerhouses that keep cells functioning properly. Several lab studies have shown that it may improve metabolic health, in particular by activating sirtuins. The Resveratrol contained in the EF ZIN,  favorably enhances the activation of cellular sirtuin proteins (longevity factors). NAD+ is required for our sirtuins to function. As we age, NAD+ levels plummet, which impedes the ability of resveratrol to deliver its benefits. When sirtuins are activated, the  end result is delayed ageing, which has been demonstrated in a wide spectrum of experimental models, including mammals. Sirtuins that are activated by resveratrol require NAD+ as their energy substrate. Loss of NAD+ impedes beneficial sirtuin function. Younger people have high NAD+ levels that enable them to benefit from the sirtuin-boosting effects of resveratrol. To improve the functionality of sirtuin proteins, it makes sense for maturing individuals to boost their NAD+ levels. The good news is that a precursor to NAD+ can be found in Vitamin B3. The dosage recommendation of EF ZIN  can enable older people to restore cellular NAD+ to more youthful profiles.

Camellia sinensis (Green tea)

Camellis sinensis has been implicated in benefiting almost every organ system in the body. It is cardioprotective, neuroprotective, anti-obesity, anti-carcinogenic, anti-diabetic, anti-artherogenic, liver protective and beneficial for blood vessel health. Camellia sinensis contains also Epigallocatechin-gallate (EGCG) that regulates multiple pathways that influnce aging in a broad range of tissues. EGCG uniquely regulates the Wnt pathway, which is vital in determining developing cells’ proper fate and preventing cancer. EGCG also prevents sugar-induced damage to tissues throughout the body, helping to suppress their pro-aging effects. Scientists found that these compounds reduced cellular aging and various processes that contributed to aging by beneficially modulating a group of signaling pathways that led to the formation of senescent cells. Most of these pathways are known to contribute to, or protect against, development of senescent cells, and all have been shown to protect against aging at the cellular level.

Vitamin B3 (Niacin)

EF ZIN contains Vitamin B3 (Niacin). Clinical research demonstrates that Niacin, is a highly efficient precursor to NAD+. Incorporating Niacin into the body has been shown to restore NAD+ levels in laboratory models, combating age-related decline in the NAD+ supply that cells experience. Preclinical studies link the restoration of NAD+ supplies to an improvement in metabolic efficiency and overall health. NAD+ is essential for energy production and DNA repair. The most important NAD+ benefit is promoting rapid DNA repair and fueling beneficial longevity proteins. Failure to repair damaged DNA can result in cell death or transformation into malignant or senescent states. NAD+ levels markedly decline with age. NAD+ deficit manifests clinically in the form of degenerative disorders of the brain, heart, and other tissues. In animal studies, regenerative effects have been observed in the brain when NAD+ is restored. Sleep quality deteriorates with normal aging in many people. Restoring youthful NAD+ levels in the brain may support a healthy circadian rhythm. Loss of NAD+ activity is linked to type II diabetes. In mice, administration of an NAD+ precursor restores insulin sensitivity and protects against the diabetic impact of a high-fat diet.

How does EF ZIN work?

Cellural Metabolism


Camellia sinensis

Sirtuins Boosting effect

Increases intracellular

NAD+ levels

Sirtuins Boosting effect

Preventing Senescence

DNA Repair



Mitochondrial Function

Energy Production


Vitamin B3 (Nicotinamide)

NAD+ Precursor

EF ZIN by boosting intracellular NAD+ levels and activating sirtuins helps to promote cellular metabolism, mitochondrial function and energy production

EF ZIN Benefits

EF ZIN is a Food Supplement scientifically formulated to support Metabolic Function and Well-Being

  • Supports healthy molecular integrity & cell metabolism
  • Increases Energy levels, mental and physical performance
  • Contributes to the reduction of tiredness and fatigue
  • Supports the immune system
  • Enriched Feeling of vitality and well-being
  • Contributes to the reduction of local thickness

Recommended for Adults

It is suitable for long-term use in adults of all age groups.

One Capsule Per Day

It is recommended a daily intake of one capsule in the morning, with or without food. Each bottle contains a 30-day supply.

No Animal Products

Vegetarian, vegan, gluten-free, nut-free, no artificial colors or flavors.

EU and EFSA recommendations

The product is manufactured under Good Manufacturing Practice (GMP) process and meets EFSA regulatory criteria.

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